Differences in the severity of the phenotype of children and adolescents with Familial Mediterranean Fever residing in Turkey and Germany

To substantiate this hypothesis we compared the diseaseseverity in Turkish FMF patients living in Turkey and Germany, based on a modified score for children. A total of 53 Turkish children living in Turkey were compared to 45 Turkish children born and raised in Germany. Mean age among the group from Turkey and Germany was 42.2 (range 2–120 months) and 44.29 (range 3–178 months) months, respectively. M694V was the leading mutation in both groups. The score developed by Livneh et al was modified by the integration of the recommended agerelated doses, previously published by us. Additionally, disease severity was determined by the use of the scoring system developed by Pras et al. There was no correlation between the disease severity defined by the different scoring systems and the acute phase reactants.